Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719446 | 0.83 | POLB (0.50) | POLBTDP1SMN1; SMN2APOBEC3AMAPT | |
| Benzylamine SCHEMBL1719444 | 0.80 | POLB (0.51) | POLBTDP1SMN1; SMN2APOBEC3AMAPT | |
| SCHEMBL1718847 | 0.76 | POLB (0.79) | POLBTDP1SMN1; SMN2APOBEC3AMAPT | |
| SCHEMBL3283065 | 0.76 | TDP1 (0.60) | POLBTDP1SMN1; SMN2APOBEC3AMAPT | |
| SCHEMBL12266355 | 0.72 | MMP13 (0.59) | SMN1; SMN2KDM4EALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL31026201 | 0.72 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1PKMKMT2AGAA | |
| SCHEMBL3817220 | 0.68 | KDM4E (0.57) | POLBSMN1; SMN2APOBEC3AMAPTKDM4E | |
| SCHEMBL31241108 | 0.66 | RAB9A (0.60) | POLBSMN1; SMN2MAPTKDM4ERAB9A | |
| SCHEMBL1269593 | 0.66 | RAB9A (0.60) | POLBSMN1; SMN2MAPTKDM4ERAB9A | |
| SCHEMBL23534535 | 0.66 | TDP1 (0.51) | POLBTDP1SMN1; SMN2APOBEC3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |