Azasetron

Azasetron

SCHEMBL17190

CN1C(=O)COc2c(C(=O)NC3CN4CCC3CC4)cc(Cl)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 3/20 1.00
KCNH2 Q12809 2/20 1.00
HTR2A P28223 1/20 1.00
SLC6A4 P31645 1/20 1.00
HRH1 P35367 1/20 1.00
PDE4D Q08499 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
CYP1A2 P05177 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azasetron SCHEMBL19492326 1.00 HTR3A (1.00) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL17191 1.00 HTR3A (1.00) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL13186328 1.00 HTR3A (1.00) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL29880168 1.00 HTR3A (1.00) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL19463750 1.00 HTR3A (1.00) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL1023863 0.99 HTR3A (0.98) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL442156 0.99 HTR3A (0.98) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL29089146 0.98 HTR3A (0.96) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL1649657 0.98 HTR3A (0.96) HTR3AKCNH2HTR2ASLC6A4HRH1
Azasetron SCHEMBL19463074 0.94 HTR3A (0.89) HTR3AKCNH2HTR2ASLC6A4HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 10866 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144776-A1 COMBINATION THERAPY FOR A DOPAMINE AGONIST ALTO NEUROSCIENCE, INC. (US) 2026-05-28 US claimed
EP-4739318-A1 AZASETRON FOR THE PRESERVATION OF RESIDUAL HEARING FOLLOWING COCHLEAR IMPLANTATION Sensorion (FR) 2026-05-13 EP claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
EP-3615024-B1 COMPOSITIONS COMPRISING PRAMIPEXOLE AND A 5HT3 ANTAGONIST FOR USE IN TREATING DEPRESSION ALTO NEUROSCIENCE INC (US) 2026-02-18 EP claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
US-20250222003-A1 PHARMACEUTICAL COMPOSITION FOR TREATING SOLID TUMORS EISAI R&D MANAGEMENT CO., LTD. (JP) 2025-07-10 US claimed
US-20250170139-A1 AZASETRON FOR THE TREATMENT OF SUDDEN SENSORINEURAL HEARING LOSS SENSORION (FR) 2025-05-29 US claimed
WO-2025077727-A1 USE OF PEPTIDE AMIDE COMPOUND IN PREPARATION OF DRUG FOR PREVENTING NAUSEA AND VOMITING 海思科医药集团股份有限公司 2025-04-17 WO claimed
WO-2025008371-A1 AZASETRON FOR THE PRESERVATION OF RESIDUAL HEARING FOLLOWING COCHLEAR IMPLANTATION SENSORION (FR) 2025-01-09 WO claimed
CN-109259908-B Novel drug-loaded airway stent and preparation method thereof 广州医科大学 2024-12-31 CN claimed
EP-0975327-A1 USE OF 5HT3 ANTAGONISTS FOR PROMOTING INTESTINAL LAVAGE JANSSEN PHARMACEUTICA N.V. (BE) 2000-02-02 EP claimed
WO-1999017755-A2 MEDICAMENTS GLAXO GROUP LIMITED (GB) 1999-04-15 WO claimed
CN-1201390-A 5-HT3 receptor antagonists for treating dyskinesia GLAXO WELLCOME INC (GB) 1998-12-09 CN claimed
WO-1998047481-A1 USE OF 5HT3 ANTAGONISTS FOR PROMOTING INTESTINAL LAVAGE JANSSEN PHARMACEUTICA N.V. (BE) 1998-10-29 WO claimed
EP-0851756-A1 5-HT 3? RECEPTOR ANTAGONISTS FOR DYSKINESIA GLAXO GROUP LIMITED (GB) 1998-07-08 EP claimed
WO-1997047285-A1 GASTRIC-RETENTIVE ORAL CONTROLLED DRUG DELIVERY SYSTEM WITH ENHANCED RETENTION PROPERTIES DEPOMED, INC. (US) 1997-12-18 WO claimed
WO-1997010823-A1 5-HT3 RECEPTOR ANTAGONISTS FOR DYSKINESIA GLAXO GROUP LIMITED (GB) 1997-03-27 WO claimed
EP-0313393-B1 Benzoxazine compounds and pharmaceutical use thereof YOSHITOMI PHARMACEUTICAL (JP) 1994-03-16 EP claimed
US-4892872-A ANTIEMETICS, ANTINAUSEA YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1990-01-09 US claimed
EP-0313393-A2 Benzoxazine compounds and pharmaceutical use thereof Yoshitomi Pharmaceutical Industries, Ltd. (JP) 1989-04-26 EP claimed