Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Azasetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.96 |
| ▸ | HTR2A | P28223 | 1/20 | 0.96 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.96 |
| ▸ | HRH1 | P35367 | 1/20 | 0.96 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.96 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azasetron SCHEMBL29089146 | 0.98 | HTR3A (0.96) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL29880168 | 0.98 | HTR3A (1.00) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL17190 | 0.98 | HTR3A (1.00) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL13186328 | 0.98 | HTR3A (1.00) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL19463750 | 0.98 | HTR3A (1.00) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL17191 | 0.98 | HTR3A (1.00) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL19492326 | 0.98 | HTR3A (1.00) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL1023863 | 0.97 | HTR3A (0.98) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL442156 | 0.97 | HTR3A (0.98) | HTR3AKCNH2HTR2ASLC6A4HRH1 | |
| Azasetron SCHEMBL19463074 | 0.93 | HTR3A (0.89) | HTR3AKCNH2HTR2ASLC6A4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118435968-A | Antibacterial deodorizing spray for garbage stacking area and preparation method and application thereof | 宁波绅特英医疗健康发展有限公司 | 2024-08-06 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |