Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719021 | 0.92 | RXFP1 (0.60) | MAPTTP53PTGESPOLBALDH1A1 | |
| SCHEMBL1719819 | 0.92 | PTGES (0.66) | MAPTTP53PTGESPOLBALDH1A1 | |
| SCHEMBL1719273 | 0.90 | MAPT (0.62) | MAPTPTGESALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1720004 | 0.89 | HPGD (0.59) | MAPTTP53PTGESPOLBALDH1A1 | |
| SCHEMBL1719847 | 0.85 | MAPT (0.66) | MAPTPTGESALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1718225 | 0.84 | TP53 (0.78) | MAPTTP53POLBALDH1A1CYP1A2 | |
| SCHEMBL1718851 | 0.84 | MAPT (0.68) | MAPTPTGESALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1718513 | 0.84 | MAPT (0.64) | MAPTTP53PTGESALDH1A1CYP1A2 | |
| SCHEMBL1718509 | 0.83 | MAPT (0.64) | MAPTTP53PTGESALDH1A1CYP1A2 | |
| SCHEMBL1718229 | 0.83 | MAPT (0.64) | MAPTPTGESALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |