Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | FUBP1 | Q96AE4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718181 | 0.87 | MAPT (0.73) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1718015 | 0.86 | MAPT (0.60) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1717779 | 0.86 | ALDH1A1 (0.83) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1719293 | 0.84 | MAPT (0.65) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1718780 | 0.83 | MAPT (0.74) | MAPTALDH1A1HPGDNPSR1KDM4E | |
| SCHEMBL1719287 | 0.82 | MAPT (0.78) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL12239908 | 0.81 | KDM4E (0.67) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1717810 | 0.78 | MAPT (0.57) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1718286 | 0.78 | MAPT (0.69) | MAPTALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1717821 | 0.78 | ALDH1A1 (0.77) | MAPTALDH1A1HPGDNPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |