Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.69 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719275 | 0.85 | PTGES (0.58) | MAPTRXFP1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL1719993 | 0.85 | MAPT (0.69) | MAPTTHRBRXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1718181 | 0.84 | MAPT (0.73) | MAPTTHRBRXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1719287 | 0.84 | MAPT (0.78) | MAPTTHRBRXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1719273 | 0.82 | MAPT (0.62) | MAPTTHRBRXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1719006 | 0.81 | MAPT (0.62) | MAPTTHRBRXFP1ALDH1A1HPGD | |
| SCHEMBL1718289 | 0.80 | MAPT (0.66) | MAPTTHRBRXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1718060 | 0.80 | PTGES (0.69) | MAPTTHRBRXFP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1720004 | 0.80 | HPGD (0.59) | MAPTTHRBRXFP1ALDH1A1HPGD | |
| SCHEMBL1718043 | 0.80 | ALDH1A1 (0.65) | MAPTTHRBRXFP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |