Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718632 | 0.88 | THRB (0.75) | THRBRXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL1718520 | 0.88 | THRB (0.75) | THRBRXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL1719068 | 0.88 | THRB (0.74) | THRBRXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL1720222 | 0.87 | THRB (0.77) | THRBRXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL1720003 | 0.85 | THRB (0.72) | THRBRXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL1719861 | 0.84 | MAPT (0.63) | THRBTP53MAPTSMN1; SMN2TTR | |
| SCHEMBL1717993 | 0.84 | THRB (0.65) | THRBRXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL1718462 | 0.80 | MAPT (0.59) | THRBRXFP1TP53MAPTSMN1; SMN2 | |
| SCHEMBL1718600 | 0.80 | KDM4E (0.73) | THRBRXFP1TP53MAPTKDM4E | |
| SCHEMBL1718681 | 0.80 | KDM4E (0.70) | THRBRXFP1TP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |