Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720222 | 0.95 | THRB (0.77) | THRBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL1717993 | 0.93 | THRB (0.65) | THRBMAPTSMN1; SMN2RXFP1TP53 | |
| SCHEMBL1719861 | 0.88 | MAPT (0.63) | THRBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL1719281 | 0.85 | THRB (0.70) | THRBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL1719069 | 0.84 | PTGES (0.60) | THRBMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1718532 | 0.84 | THRB (0.84) | THRBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL1718458 | 0.84 | THRB (0.83) | THRBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL1719619 | 0.83 | THRB (0.54) | THRBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL1719991 | 0.83 | THRB (0.82) | THRBMAPTALDH1A1HSD17B10HPGD | |
| SCHEMBL1718362 | 0.81 | THRB (0.82) | THRBMAPTALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |