Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 3/20 | 0.46 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7798239 | 0.89 | CYP26A1 (0.57) | CYP24A1CYP27A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL10754664 | 0.88 | CYP26A1 (0.49) | CYP24A1CYP27A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL17211829 | 0.88 | CYP24A1 (0.44) | CYP24A1CYP27A1METAP1CYP26A1ITGB3 | |
| SCHEMBL14061633 | 0.86 | CYP24A1 (0.60) | CYP24A1CYP27A1METAP1CYP26A1ITGB3 | |
| SCHEMBL8536553 | 0.84 | DGAT1 (0.57) | CYP24A1CYP27A1METAP1CYP26A1ITGB3 | |
| SCHEMBL14061860 | 0.83 | DGAT1 (0.50) | CYP24A1CYP27A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL16077453 | 0.83 | PPARD (0.53) | CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL13284781 | 0.83 | PPARD (0.53) | CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL4096787 | 0.83 | CYP24A1 (0.50) | CYP24A1CYP27A1CYP26A1CYP11B1CYP11B2 | |
| SCHEMBL13774776 | 0.83 | CYP24A1 (0.50) | CYP24A1CYP27A1CYP26A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624174-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE LLC (US) | 2017-04-18 | — | — | US | disclosed |
| US-20160068487-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC | 2016-03-10 | — | — | US | disclosed |
| US-9242929-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-01-26 | — | — | US | disclosed |
| US-9221766-B2 | Compounds as diacylglycerol acyltransferase inhibitors | GLAXOSMITHKLINE LLC (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150307445-A1 | Novel Compounds as Diacylglycerol Acyltransferase Inhibitors | GlaxoSmith Kline Intellectual Property (No.2) Limited (GB) | 2015-10-29 | — | — | US | disclosed |
| US-20150299138-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299138-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | DGAT1, DGAT2, LCAT | CYP24A1 562/4885CYP27A1 160/4885METAP1 692/4885 |
| US-20150307445-A1 | Novel Compounds as Diacylglycerol Acyltransferase Inhibitors | DGAT1, DGAT2, LCAT | CYP24A1 1522/4885CYP27A1 211/4885METAP1 1077/4885 |
| US-20160068487-A1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | DGAT1, DGAT2, LCAT | CYP24A1 562/4885CYP27A1 160/4885METAP1 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.