Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12263051 | 0.84 | GABRA1 (0.38) | CHRNB4CHRNA3GABRA1GABRB1 | |
| SCHEMBL3592509 | 0.82 | CHRNB4 (0.34) | CHRNB4CHRNA3GABRA1GABRB1 | |
| SCHEMBL29988864 | 0.82 | CHRNB4 (0.34) | CHRNB4CHRNA3GABRA1GABRB1 | |
| SCHEMBL1194575 | 0.81 | CHRNB4 (0.36) | CHRNB4CHRNA3 | |
| SCHEMBL28989624 | 0.80 | GABRA1 (0.35) | CHRNB4CHRNA3GABRA1GABRB1 | |
| SCHEMBL20145485 | 0.80 | GBA1 (0.36) | CHRNB4CHRNA3GABRA1GABRB1 | |
| SCHEMBL1006029 | 0.80 | GBA1 (0.36) | CHRNB4CHRNA3GABRA1GABRB1 | |
| SCHEMBL2422394 | 0.80 | GABRA1 (0.35) | CHRNB4CHRNA3GABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL31226763 | 0.78 | IDO1 (0.39) | CHRNB4CHRNA3GABRA1GABRB1 | |
| Methoxymethane SCHEMBL27702888 | 0.78 | GABRA1 (0.34) | CHRNB4CHRNA3GABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275254-A1 | PYRAZOLES | JANSSEN PHARMACEUTICALS INC (US) | 2017-09-28 | — | — | US | disclosed |
| WO-2015158427-A1 | HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275254-A1 | PYRAZOLES | GRIN3A, GRIN1, GRIN2B | CHRNB4 232/4885CHRNA3 66/4885GABRA1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.