Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 1.00 |
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.70 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.68 |
| ▸ | CDK9 | P50750 | 1/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.68 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23069083 | 0.92 | RAB9A (0.86) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL3633396 | 0.92 | NPC1 (0.84) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL11059378 | 0.85 | SMN1; SMN2 (0.94) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL4918597 | 0.85 | KMT2A (1.00) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL4110351 | 0.84 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL1128154 | 0.84 | KMT2A (0.78) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL9478869 | 0.83 | MAPT (0.71) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL23069090 | 0.83 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL19501793 | 0.83 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 | |
| SCHEMBL1019968 | 0.83 | EPHX2 (0.74) | RAB9ANPC1SMN1; SMN2MAPTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155675-B1 | KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH | PROVID PHARMACEUTICALS INC (US) | 2014-02-19 | — | — | EP | disclosed |
| EP-1891072-B1 | Substituted 7,8-Dihydro-1H-pyrimido[4,5-b]diazepin-4-amines as kinase inhibitors | ABBOTT LAB (US) | 2012-01-11 | — | — | EP | disclosed |
| US-20110105476-A1 | SUBSTITUTED 7,8-DIHYDRO-1HPYRIMIDO[4,5-B]DIAZEPIN-4-AMINES ARE NOVEL KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | US | disclosed |
| US-7795248-B2 | Substituted 7,8-dihydro-1H-pyrimido[4,5-B][1,4]diazepin-4-amines are novel kinase inhibitors | ABBOTT LABORATORIES, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| EP-1891072-A2 | SUBSTITUTED 7, 8-DIHYDRO-1H-PYRIMIDO[4,5-B][1,4] DIAZEPIN-4-AMINES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2008-02-27 | — | — | EP | disclosed |
| US-20060270663-A1 | Substituted 7,8-dihydro-1H-pyrimido[4,5-b][1,4]diazepin-4-amines are novel kinase inhibitors | ABBVIE INC. | 2006-11-30 | — | — | US | disclosed |
| WO-2006124813-A2 | SUBSTITUTED 7, 8-DIHYDRO-1H-PYRIMIDO [4,5-B] [1,4] DIAZEPIN-4-AMINES AS?KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270663-A1 | Substituted 7,8-dihydro-1H-pyrimido[4,5-b][1,4]diazepin-4-amines are novel kinase inhibitors | ABL1, MAP4K2, MAP3K7 | RAB9A 1573/4885NPC1 3180/4885SMN1; SMN2 4443/4885 |
| US-20110105476-A1 | SUBSTITUTED 7,8-DIHYDRO-1HPYRIMIDO[4,5-B]DIAZEPIN-4-AMINES ARE NOVEL KINASE INHIBITORS | ABL1, CDK5, CDK7 | RAB9A 1578/4885NPC1 3348/4885SMN1; SMN2 4200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.