Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | FABP1 | P07148 | 1/20 | 0.57 |
| ▸ | FABP6 | P51161 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853078 | 0.91 | KMT2A (0.70) | FAAHALDH1A1KMT2ATSHRKDM4E | |
| SCHEMBL5774801 | 0.86 | FAAH (0.57) | FAAHCYP2D6ALDH1A1PKMKMT2A | |
| SCHEMBL3602222 | 0.82 | FAAH (1.00) | FAAHTSHRNPC1RAB9AHTT | |
| SCHEMBL27744585 | 0.81 | KMT2A (0.58) | FAAHALDH1A1KMT2ATSHRKDM4E | |
| SCHEMBL27663681 | 0.81 | ALDH1A1 (0.70) | FAAHALDH1A1KMT2ATSHRKDM4E | |
| SCHEMBL27683352 | 0.80 | KMT2A (0.58) | FAAHALDH1A1KMT2ATSHRKDM4E | |
| SCHEMBL2592454 | 0.80 | FAAH (0.71) | FAAHCYP2D6ALDH1A1KMT2ATSHR | |
| SCHEMBL5369043 | 0.79 | FAAH (0.50) | FAAHCYP2D6ALDH1A1PKMKMT2A | |
| SCHEMBL31708753 | 0.79 | FAAH (0.64) | FAAHCYP2D6ALDH1A1PKMKMT2A | |
| SCHEMBL1064531 | 0.79 | ALDH1A1 (0.71) | FAAHALDH1A1KMT2ATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937341-A1 | 4-(BENZYL)-PIPERAZINE-1-CARBOXYLIC ACID PHENYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE (FAAH) FOR THE TREATMENT OF ANXIETY, PAIN AND OTHER CONDITIONS | Janssen Pharmaceutica N.V. (BE) | 2015-10-28 | — | — | EP | disclosed |