Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274225 | 0.73 | CA12 (0.45) | ALDH1A1NPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7666245 | 0.72 | SMN1; SMN2 (0.45) | ALDH1A1MAPTSMN1; SMN2ATMKMT2A | |
| SCHEMBL1466714 | 0.71 | ALDH1A1 (0.48) | ALDH1A1NPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL29953139 | 0.69 | ERN1 (0.35) | ALDH1A1HTTKMT2AMEN1CYP1A2 | |
| SCHEMBL18297654 | 0.69 | ERN1 (0.35) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29954202 | 0.67 | ALDH1A1 (0.38) | ALDH1A1NPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL18795405 | 0.67 | ALDH1A1 (0.38) | ALDH1A1NPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL11144934 | 0.66 | ALDH1A1 (0.44) | ALDH1A1NPSR1MAPTHTTSMN1; SMN2 | |
| SCHEMBL27227418 | 0.66 | ALDH1A1 (0.37) | ALDH1A1MAPTHTTSMN1; SMN2KMT2A | |
| SCHEMBL3969958 | 0.65 | ALDH1A1 (0.48) | ALDH1A1HTTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108341799-B | Novel indole derivatives for the treatment of cancer, viral infections and lung diseases | 生物控制术公司 | 2022-01-25 | — | — | CN | disclosed |
| US-10851054-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | BIOKINESIS (FR) | 2020-12-01 | — | — | US | disclosed |
| US-20190169124-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | DIACCURATE (FR) | 2019-06-06 | — | — | US | disclosed |
| US-10189782-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | BIOKINESIS (FR) | 2019-01-29 | — | — | US | disclosed |
| CN-108341799-A | For treating cancer, the novel indole derivative of virus infection and tuberculosis | 生物控制术公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-104854088-B | Novel indole derivatives for the treatment of cancer, viral infections and lung diseases | 生物控制术公司 | 2018-02-16 | — | — | CN | disclosed |
| US-20170233342-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | DIACCURATE (FR) | 2017-08-17 | — | — | US | disclosed |
| US-9643923-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | BIOKINESIS (FR) | 2017-05-09 | — | — | US | disclosed |
| US-20150307450-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-10-29 | — | — | US | disclosed |
| CN-104854088-A | Novel indole derivatives for the treatment of cancer, viral infections and lung diseases | BIOKINESIS | 2015-08-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169124-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | IDO2, IDO1, ING2 | ALDH1A1 2891/4885NPSR1 1516/4885MAPT 3437/4885 |
| US-20150307450-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | IDO2, IDO1, ING2 | ALDH1A1 2891/4885NPSR1 1516/4885MAPT 3437/4885 |
| US-10189782-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | IDO2, IDO1, ING2 | ALDH1A1 2533/4885NPSR1 1837/4885MAPT 3706/4885 |
| US-20170233342-A1 | NEW DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES | IDO2, IDO1, ING2 | ALDH1A1 2891/4885NPSR1 1516/4885MAPT 3437/4885 |
| US-10851054-B2 | Derivatives of indole for the treatment of cancer, viral infections and lung diseases | IDO2, IDO1, ING2 | ALDH1A1 2533/4885NPSR1 1837/4885MAPT 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.