Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 18/20 | 0.57 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208473 | 0.90 | DRD1 (0.58) | DRD1DRD5 | |
| SCHEMBL16338221 | 0.82 | DRD1 (0.58) | DRD1SMN1; SMN2 | |
| SCHEMBL15667279 | 0.79 | DRD1 (0.43) | DRD1DRD5 | |
| SCHEMBL30362362 | 0.75 | DRD1 (0.61) | DRD1DRD5 | |
| SCHEMBL16337888 | 0.75 | DRD1 (0.61) | DRD1DRD5 | |
| SCHEMBL19479309 | 0.75 | DRD1 (0.38) | DRD1DRD5 | |
| SCHEMBL17201622 | 0.73 | DRD1 (1.00) | DRD1DRD5 | |
| SCHEMBL17200280 | 0.67 | ESR1 (0.48) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL16335142 | 0.67 | LMNA (0.39) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL16337648 | 0.67 | DRD1 (0.61) | DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850232-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-9850232-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-9850232-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-9540352-B2 | Substituted 1,7-naphthyridines as dopamine D1 ligands | PFIZER INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540352-B2 | Substituted 1,7-naphthyridines as dopamine D1 ligands | PFIZER INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540352-B2 | Substituted 1,7-naphthyridines as dopamine D1 ligands | PFIZER INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20160200711-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160200711-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160200711-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2016-07-14 | — | — | US | disclosed |
| WO-2015162516-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | WO | disclosed |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200711-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | DRD1 2/4885DRD5 33/4885SMN1; SMN2 1446/4885 |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | DRD1 2/4885DRD5 33/4885SMN1; SMN2 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.