⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8568913 | 0.98 | MAPT (0.42) | — | |
| SCHEMBL11616249 | 0.85 | TSHR (0.35) | — | |
| SCHEMBL421346 | 0.79 | — | — | |
| SCHEMBL125624 | 0.79 | — | — | |
| SCHEMBL19386249 | 0.77 | TSHR (0.52) | — | |
| SCHEMBL10067112 | 0.76 | LMNA (0.32) | — | |
| SCHEMBL11618480 | 0.76 | EPHX1 (0.36) | — | |
| SCHEMBL10435535 | 0.73 | — | — | |
| SCHEMBL11612026 | 0.72 | EPHX1 (0.42) | — | |
| SCHEMBL11613493 | 0.72 | EPHX1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1617873-B1 | Treatment of multi-drug resistant tumours by a conjugate of mitomycin C | ALZA CORP (US) | 2012-01-18 | — | — | EP | disclosed |
| US-7608687-B2 | Releasable linkage and compositions containing same | ALZA CORPORATION (US) | 2009-10-27 | — | — | US | disclosed |
| US-7592307-B2 | Releasable linkage and compositions containing same | ALZA CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-20080279922-A1 | Releasable linkage and compositions containing same | ALZA CORPORATION | 2008-11-13 | — | — | US | disclosed |
| US-20080152702-A1 | Releasable linkage and compositions containing same | ZALIPSKY SAMUEL | 2008-06-26 | — | — | US | disclosed |
| US-7390780-B2 | Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification | ALZA CORPORATION (US) | 2008-06-24 | — | — | US | disclosed |
| EP-1880736-A1 | Releasable linkage and composition containing same | Alza Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| US-7303760-B2 | Method for treating multi-drug resistant tumors | ALZA CORPORATION (US) | 2007-12-04 | — | — | US | disclosed |
| US-7285622-B2 | Releasable linkage and compositions containing same | ALZA CORPORATION (US) | 2007-10-23 | — | — | US | disclosed |
| US-7276248-B2 | Conjugate having a cleavable linkage for use in a liposome | ALZA CORPORATION (US) | 2007-10-02 | — | — | US | disclosed |
| US-20020192275-A1 | Liposome composition for improved intracellular delivery of a therapeutic agent | ALZA CORPORATION | 2002-12-19 | — | — | US | disclosed |
| WO-2002076428-A1 | LIPOSOME COMPOSITION FOR IMPROVED INTRACELLULAR DELIVERY OF A THERAPEUTIC AGENT | ALZA CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |
| US-20020128195-A1 | Releasable linkage and compositions containing same | ALZA CORPORATION | 2002-09-12 | — | — | US | disclosed |
| CN-1355713-A | Releasable bond and composition containing the same | ALZA CORP (US) | 2002-06-26 | — | — | CN | disclosed |
| US-6365179-B1 | CONJUGATE FOR USE IN LIPOSOMAL DRUG-DELIVERY VEHICLE INCLUDING HYDROPHOBIC MOIETY SUITABLE FOR INCORPORATION INTO LIPOSOMAL LIPID BILAYER AND THERAPEUTIC DRUG COVALENTLY ATTACHED TO DITHIOBENZYL MOIETY IN ORTHO OR PARA POSITION | ALZA CORPORATION | 2002-04-02 | — | — | US | disclosed |
| US-6342244-B1 | HYDROPHILIC POLYMER COVALENTLY YET REVERSIBLY LINKED TO A AMINE-CONTAINING LIGAND THROUGH A DITHIOBENZYL LINKAGE; MODIFICATION OF VARIOUS SUBSTRATES, SUCH AS POLYPEPTIDES, DRUGS AND LIPOSOMES; UPON CLEAVAGE OF THE LINKAGE, THE LIGAND | ALZA CORPORATION | 2002-01-29 | — | — | US | disclosed |
| EP-1173221-A2 | RELEASABLE LINKAGE AND COMPOSITIONS CONTAINING SAME | Alza Corporation (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-1173222-A2 | CONJUGATE HAVING A CLEAVABLE LINKAGE FOR USE IN A LIPOSOME | ALZA CORPORATION (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064484-A2 | CONJUGATE HAVING A CLEAVABLE LINKAGE FOR USE IN A LIPOSOME | ALZA CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |
| WO-2000064483-A2 | RELEASABLE LINKAGE AND COMPOSITIONS CONTAINING SAME | ALZA CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |