SCHEMBL17201767

SCHEMBL17201767

O=C(O)c1cccnc1-c1cccc(-c2ccc(Cl)cc2)n1.[KH]

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
KMO O15229 3/20 0.50
DHODH Q02127 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
MEN1 O00255 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
LMNA P02545 1/20 0.46
CTRC Q99895 2/20 0.46
CSNK2A2 P19784 1/20 0.44
CSNK2B P67870 1/20 0.44
SMO Q99835 1/20 0.43
PDE4A P27815 1/20 0.43
PDE4C Q08493 1/20 0.43
PDE4D Q08499 1/20 0.43
PARP1 P09874 1/20 0.42
ALDH1A1 P00352 2/20 0.41
PTGES O14684 1/20 0.41
ALOX5 P09917 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15567980 0.99 KDM4E (0.54) KDM4ETDP1KMODHODHSMN1; SMN2
Potassium SCHEMBL17201770 0.97 KDM4E (0.53) KDM4ETDP1KMODHODHSMN1; SMN2
SCHEMBL15467862 0.87 KDM4E (0.61) KDM4ETDP1DHODHSMN1; SMN2MEN1
SCHEMBL17201769 0.86 KDM4E (0.57) KDM4ETDP1KMODHODHSMN1; SMN2
Potassium Ion SCHEMBL17201768 0.85 KMO (0.43) KDM4ETDP1KMODHODHSMN1; SMN2
SCHEMBL17201766 0.85 KDM4E (0.58) KDM4ETDP1KMODHODHSMN1; SMN2
SCHEMBL15569111 0.83 NPC1 (0.55) TDP1KMOSMN1; SMN2RAB9ALMNA
SCHEMBL31676801 0.82 KDM4E (0.67) KDM4ETDP1KMODHODHSMN1; SMN2
SCHEMBL6924541 0.82 KDM4E (0.67) KDM4ETDP1KMODHODHSMN1; SMN2
SCHEMBL15569110 0.81 KDM4E (0.53) KDM4ETDP1KMODHODHSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9409881-B2 Herbicidally active 6′-phenyl-2,2′-bipyridine-3-carboxylic acid derivatives BAYER CROPSCIENCE AG (AG) 2016-08-09 US disclosed
US-20150307470-A1 HERBICIDALLY ACTIVE 6'-PHENYL-2,2'-BIPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES BAYER CROPSCIENCE AG (DE) 2015-10-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150307470-A1 HERBICIDALLY ACTIVE 6'-PHENYL-2,2'-BIPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES CBR3, DDT, CBR1 KDM4E 3718/4885TDP1 1074/4885KMO 574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.