Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 5/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 5/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | MTOR | P42345 | 6/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201937 | 0.96 | DYRK1A (0.45) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL17210359 | 0.87 | MAP3K12 (0.43) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL17202027 | 0.83 | MAP3K12 (0.47) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL17210369 | 0.83 | MAP3K12 (0.47) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL18539056 | 0.83 | MAP3K12 (0.47) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL17202180 | 0.80 | TRPA1 (0.40) | DYRK1APIK3CAMTORPIK3R1 | |
| SCHEMBL24942475 | 0.78 | DYRK1A (0.51) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL24942471 | 0.78 | DYRK1A (0.51) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL28392709 | 0.78 | MAP3K12 (0.40) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 | |
| SCHEMBL28388770 | 0.78 | MTOR (0.46) | DYRK1ASMARCA2SMARCA4PBRM1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134410-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | Hydra Biosciences, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015164643-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | HYDRA BIOSCIENCES, INC. (US) | 2015-10-29 | — | — | WO | disclosed |