Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 13/20 | 0.47 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201969 | 0.87 | PTPN11 (0.39) | PTPN11KCNK2SCN2AROCK2 | |
| SCHEMBL17202011 | 0.86 | GSK3A (0.37) | PTPN11GSK3AGSK3BTRPV3PIK3CA | |
| SCHEMBL22119525 | 0.81 | OGA (0.44) | PTPN11GSK3AGSK3BTRPV3PIK3CA | |
| SCHEMBL17610067 | 0.77 | DYRK1A (0.41) | PTPN11KCNK2SCN2A | |
| SCHEMBL17201967 | 0.77 | PTPN11 (0.38) | PTPN11PIK3CAMTOR | |
| SCHEMBL26975257 | 0.73 | PTPN11 (0.46) | PTPN11TRPV3PRKCAPRKCQ | |
| SCHEMBL17201976 | 0.72 | MAP3K12 (0.34) | PIK3CAMTORROCK2 | |
| SCHEMBL17201937 | 0.71 | DYRK1A (0.45) | PIK3CAMTOR | |
| SCHEMBL17202180 | 0.71 | TRPA1 (0.40) | PTPN11PIK3CAMTOR | |
| SCHEMBL17201952 | 0.70 | DYRK1A (0.42) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134410-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | Hydra Biosciences, Inc. (US) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015164643-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | HYDRA BIOSCIENCES, INC. (US) | 2015-10-29 | — | — | WO | disclosed |