Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186716 | 0.82 | ALDH1A1 (0.38) | HRH3ALDH1A1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL5807819 | 0.77 | HRH3 (0.48) | HRH3ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL947690 | 0.77 | HRH3 (0.48) | HRH3ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL29956822 | 0.77 | HRH3 (0.48) | HRH3ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL5489927 | 0.76 | HRH3 (0.52) | HRH3ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL11179141 | 0.76 | HRH3 (0.52) | HRH3ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL5233749 | 0.74 | CHRNB2 (0.41) | HRH3ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL678885 | 0.74 | — | — | |
| SCHEMBL5466976 | 0.74 | CHRNB2 (0.41) | HRH3ALDH1A1MAPTPOLBL3MBTL1 | |
| SCHEMBL10846103 | 0.73 | HRH3 (0.48) | HRH3ALDH1A1MAPTPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802591-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-01-11 | — | — | EP | disclosed |