SCHEMBL172038

SCHEMBL172038

CCCc1cc(F)c(F)c(F)c1F

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.36
HDAC3 O15379 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
CTSL P07711 1/20 0.31
CTSS P25774 1/20 0.31
CTSK P43235 1/20 0.31
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
XBP1 P17861 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27959502 0.85 ALOX5 (0.43) MAPT
SCHEMBL20226527 0.82 HMGCR (0.34) HMGCR
SCHEMBL15702934 0.82 HMGCR (0.34) HMGCR
SCHEMBL8082934 0.82 HMGCR (0.34) HMGCRMAPT
SCHEMBL6634488 0.80 HDAC3 (0.39) HDAC3HDAC6
SCHEMBL12107903 0.79 HMGCR (0.41) HMGCRLMNAMAPTXBP1HIF1A
SCHEMBL10061120 0.79 RIPK1 (0.42) HMGCRLMNAMAPTXBP1HIF1A
SCHEMBL29661802 0.78 TAAR1 (0.30)
SCHEMBL6284487 0.78 TAAR1 (0.44) MAPT
SCHEMBL22011782 0.77 HMGCR (0.34) HMGCR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2426558-A1 Silicon-containing film-forming composition, silicon-containing film-formed substrate, and patterning process Shin-Etsu Chemical Co., Ltd. (JP) 2012-03-07 EP disclosed