Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTBP2 | P56545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17204261 | 1.00 | CTBP2 (0.48) | CTBP2ALDH1A1MAPK8KDM4EMAPT | |
| SCHEMBL30172840 | 1.00 | CTBP2 (0.48) | CTBP2ALDH1A1MAPK8KDM4EMAPT | |
| SCHEMBL30768637 | 0.85 | CTBP2 (0.49) | CTBP2ALDH1A1KDM4EMAPTCYP1A2 | |
| SCHEMBL4317748 | 0.83 | CTBP2 (0.56) | CTBP2ALDH1A1MAPK8IDO1AGXT | |
| SCHEMBL4317744 | 0.83 | CTBP2 (0.56) | CTBP2ALDH1A1MAPK8IDO1AGXT | |
| SCHEMBL3179495 | 0.83 | CTBP2 (0.47) | CTBP2ALDH1A1KDM4EMAPTTAAR1 | |
| SCHEMBL8949906 | 0.82 | MAPT (0.47) | ALDH1A1MAPTTSHRMAPK1L3MBTL1 | |
| SCHEMBL8949899 | 0.82 | MAPT (0.47) | ALDH1A1MAPTTSHRMAPK1L3MBTL1 | |
| SCHEMBL511950 | 0.79 | POLB (0.56) | CTBP2ALDH1A1KDM4EMAPTCYP1A2 | |
| SCHEMBL29640755 | 0.79 | POLB (0.56) | CTBP2ALDH1A1KDM4EMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111620870-B | Compound and application thereof in expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | 蒙特利尔大学 | 2023-01-03 | — | — | CN | disclosed |
| CN-111620870-A | Compound and application thereof in expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | 蒙特利尔大学 | 2020-09-04 | — | — | CN | disclosed |
| CN-106414445-B | Compound and application thereof in expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | 蒙特利尔大学 | 2020-07-03 | — | — | CN | disclosed |
| US-10647718-B2 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | Universitéde Montréal (CA) | 2020-05-12 | — | — | US | disclosed |
| EP-3134409-B1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIV MONTREAL (CA) | 2020-02-12 | — | — | EP | disclosed |
| EP-3134409-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | Université de Montréal (CA) | 2017-03-01 | — | — | EP | disclosed |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | UNIVERSITE DE MONTREAL (CA) | 2017-02-09 | — | — | US | disclosed |
| WO-2015161373-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | Université de Montréal (CA) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647718-B2 | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells | HPGDS, HCLS1, THPO | CTBP2 3440/4885ALDH1A1 19/4885MAPK8 2731/4885 |
| US-20170037047-A1 | COMPOUNDS AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS AND/OR HEMATOPOIETIC PROGENITOR CELLS | HPGDS, HCLS1, THPO | CTBP2 3440/4885ALDH1A1 19/4885MAPK8 2731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.