Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | APAF1 | O14727 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | CASP6 | P55212 | 1/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 1/20 | 1.00 |
| ▸ | APBA1 | Q02410 | 1/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 1.00 |
| ▸ | CASP8 | Q14790 | 1/20 | 1.00 |
| ▸ | CDC25B | P30305 | 2/20 | 0.68 |
| ▸ | FABP4 | P15090 | 3/20 | 0.64 |
| ▸ | FABP3 | P05413 | 2/20 | 0.64 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.64 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.61 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.61 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | CTSV | O60911 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29441241 | 1.00 | KDM4E (1.00) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL9953717 | 0.92 | KDM4E (0.85) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL9953689 | 0.91 | KDM4E (0.83) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL23286069 | 0.91 | KDM4E (0.83) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL10074402 | 0.89 | KDM4E (0.79) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL10075677 | 0.88 | KDM4E (0.79) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL10074883 | 0.88 | KDM4E (0.77) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL9954168 | 0.88 | KDM4E (0.77) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL9952450 | 0.87 | KDM4E (0.77) | KDM4EAPAF1RECQLCASP6CACNA1B | |
| SCHEMBL19341855 | 0.87 | KDM4E (0.76) | KDM4EAPAF1RECQLCASP6CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4302833-A2 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | Augusta University Research Institute, Inc. (US) | 2024-01-10 | — | — | EP | claimed |
| EP-3548022-B1 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | UNIV RES INST INC AUGUSTA (US) | 2023-11-22 | — | — | EP | claimed |
| EP-3548022-A1 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | Augusta University Research Institute, Inc. (US) | 2019-10-09 | — | — | EP | claimed |
| WO-2018100556-A1 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. (US) | 2018-06-07 | — | — | WO | claimed |
| US-20180153898-A1 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. | 2018-06-07 | — | — | US | claimed |
| EP-2655334-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | Eutropics Pharmaceuticals, Inc. (US) | 2013-10-30 | — | — | EP | claimed |
| US-20120225851-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | EUTROPICS PHARMACEUTICALS, INC. (US) | 2012-09-06 | — | — | US | claimed |
| WO-2012088438-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | EUTROPICS PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | claimed |
| EP-4302833-A2 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | Augusta University Research Institute, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| EP-3548022-B1 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | UNIV RES INST INC AUGUSTA (US) | 2023-11-22 | — | — | EP | disclosed |
| US-20220387362-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | RHIZEN PHARMACEUTICALS AG (CH) | 2022-12-08 | — | — | US | disclosed |
| US-20210379070-A1 | MALONATE SALT OF VARLITINIB | ASLAN PHARMACEUTICALS PTE LTD (SG) | 2021-12-09 | — | — | US | disclosed |
| US-20200147091-A1 | COMPOSITIONS FOR MODULATING PD-1 SIGNAL TRANSDUCTION | AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC. | 2020-05-14 | — | — | US | disclosed |
| US-10548895-B2 | Ligands that target Plasmodium sporozoite binding sites on CD81 and therapeutic methods using them | THE AMERICAN UNIVERSITY IN CAIRO (EG) | 2020-02-04 | — | — | US | disclosed |
| US-20110275603-A1 | NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS | RHIZEN PHARMACEUTICALS SA (FR) | 2011-11-10 | — | — | US | disclosed |
| EP-2319936-A2 | Yeast screens for agents affecting protein folding | The University of Chicago (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-1392849-B1 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIV CHICAGO (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1793001-A2 | Yeast screens for agents affecting protein folding | The University of Chicago (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1392849-A2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | THE UNIVERSITY OF CHICAGO (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002065136-A2 | YEAST SCREENS FOR AGENTS AFFECTING PROTEIN FOLDING | UNIVERSITY OF CHICAGO (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225851-A1 | COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES | MCL1, BCL3, BCL9 | KDM4E 1427/4885APAF1 111/4885RECQL 627/4885 |
| US-20110275603-A1 | NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS | DHODH, DLD, DHFR | KDM4E 1861/4885APAF1 1823/4885RECQL 962/4885 |
| US-20210379070-A1 | MALONATE SALT OF VARLITINIB | KRAS, JAK1, JAK2 | KDM4E 663/4885APAF1 4073/4885RECQL 3077/4885 |
| US-20220387362-A1 | COMPOSITIONS COMPRISING A DHODH INHIBITOR FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA | DHODH, FLT3, IDH3A | KDM4E 232/4885APAF1 2155/4885RECQL 266/4885 |
| US-10548895-B2 | Ligands that target Plasmodium sporozoite binding sites on CD81 and therapeutic methods using them | CD81, HAVCR2, SELPLG | KDM4E 4814/4885APAF1 153/4885RECQL 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.