SCHEMBL17205196

SCHEMBL17205196

CCOC(=O)c1nc2cc(Br)ccc2o1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.49
ALDH1A1 P00352 2/20 0.49
XDH P47989 2/20 0.47
TARBP2 Q15633 1/20 0.47
TBK1 Q9UHD2 1/20 0.46
ALOX5 P09917 3/20 0.44
HTT P42858 1/20 0.44
MAPT P10636 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
NPC1 O15118 1/20 0.43
POLB P06746 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
LMNA P02545 1/20 0.43
TSHR P16473 1/20 0.43
ATM Q13315 1/20 0.42
SIRT2 Q8IXJ6 1/20 0.42
CETP P11597 1/20 0.41
CEPT1 Q9Y6K0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3611112 0.86 AGPAT2 (0.49) SMN1; SMN2ALDH1A1XDHTARBP2MAPT
SCHEMBL21612949 0.84 XDH (0.47) SMN1; SMN2ALDH1A1XDHHTTMAPT
SCHEMBL30601063 0.83 RAB9A (0.50) SMN1; SMN2ALDH1A1HTTMAPTKDM4E
SCHEMBL29259228 0.83 RAB9A (0.50) SMN1; SMN2ALDH1A1HTTMAPTKDM4E
SCHEMBL10829015 0.83 MAOB (0.52) SMN1; SMN2ALDH1A1XDHTARBP2ALOX5
SCHEMBL25370721 0.83 TSHR (0.51) SMN1; SMN2ALDH1A1XDHMAPTKDM4E
SCHEMBL27243895 0.82 MAOB (0.56) ALDH1A1TARBP2HTTKDM4EMEN1
SCHEMBL3621004 0.80 RAB9A (0.53) SMN1; SMN2ALDH1A1XDHMAPTKDM4E
SCHEMBL29826477 0.77 XDH (0.55) SMN1; SMN2ALDH1A1XDHTBK1MAPT
SCHEMBL1906793 0.77 XDH (0.55) SMN1; SMN2ALDH1A1XDHTBK1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015162538-A1 HETEROCYCLIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS FOR THE TREATMENT OF HYPERPARATHYROIDISM, CHRONIC RENAL FAILURE AND CHRONIC KIDNEY DISEASE LUPIN LIMITED (IN) 2015-10-29 WO disclosed
WO-2015162538-A1 HETEROCYCLIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS FOR THE TREATMENT OF HYPERPARATHYROIDISM, CHRONIC RENAL FAILURE AND CHRONIC KIDNEY DISEASE LUPIN LIMITED (IN) 2015-10-29 WO disclosed