Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.69 |
| ▸ | JAK1 | P23458 | 15/20 | 0.69 |
| ▸ | JAK2 | O60674 | 13/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15689491 | 0.86 | TYK2 (0.68) | TYK2JAK1JAK2PDE4DJAK3 | |
| SCHEMBL15713819 | 0.86 | TYK2 (0.54) | TYK2JAK1JAK2PDE4DJAK3 | |
| SCHEMBL31139610 | 0.85 | TYK2 (0.63) | TYK2JAK1JAK2PDE4DJAK3 | |
| SCHEMBL17207248 | 0.85 | TYK2 (0.50) | TYK2JAK1JAK2PDE4DSTAT3 | |
| SCHEMBL691209 | 0.84 | ULK1 (0.51) | TYK2JAK1JAK2PDE4DMAPK8 | |
| SCHEMBL13060634 | 0.84 | MAPK10 (0.51) | TYK2JAK1JAK2PDE4DMAPK8 | |
| SCHEMBL690590 | 0.83 | MAPK10 (0.65) | TYK2JAK1JAK2MAPK8MAPK10 | |
| SCHEMBL29777593 | 0.83 | MAPK10 (0.65) | TYK2JAK1JAK2MAPK8MAPK10 | |
| SCHEMBL15689702 | 0.83 | TYK2 (0.56) | TYK2JAK1JAK2PDE4DJAK3 | |
| SCHEMBL15713530 | 0.82 | TYK2 (0.65) | TYK2JAK1JAK2PDE4DSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922841-B1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2017-06-07 | — | — | EP | disclosed |
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |
| US-20150307483-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL-MYERS SQUIBB COMPANY | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307483-A1 | ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | IFNG, TYK2, IFNAR1 | TYK2 2/4885JAK1 13/4885JAK2 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.