SCHEMBL1720736

SCHEMBL1720736

CC(=O)CC(=O)c1cccnc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLOD2 O00469 2/20 0.71
PLOD3 O60568 1/20 0.63
PLOD1 Q02809 1/20 0.63
ALDH1A1 P00352 3/20 0.58
GAA P10253 2/20 0.55
APP P05067 1/20 0.55
HCAR3 P49019 1/20 0.55
HCAR2 Q8TDS4 1/20 0.55
HDAC1 Q13547 3/20 0.55
HDAC6 Q9UBN7 1/20 0.55
THRB P10828 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
F7 P08709 1/20 0.53
F3 P13726 1/20 0.53
SARM1 Q6SZW1 1/20 0.53
SIRT2 Q8IXJ6 1/20 0.53
SIRT6 Q8N6T7 1/20 0.53
SIRT1 Q96EB6 1/20 0.53
SIRT3 Q9NTG7 1/20 0.53
SIRT5 Q9NXA8 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30489910 1.00 PLOD2 (0.71) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL10320930 0.88 PLOD2 (0.89) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL29554726 0.88 PLOD2 (0.89) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL1987632 0.84 PLOD2 (0.59) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL30440488 0.83 PLOD2 (1.00) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL2694778 0.83 PLOD2 (0.79) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL4625207 0.83 PLOD2 (1.00) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL5162475 0.82 PLOD2 (0.67) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL11624584 0.82 HDAC1 (0.63) PLOD2PLOD3PLOD1ALDH1A1GAA
SCHEMBL11809006 0.82 PLOD2 (0.67) PLOD2PLOD3PLOD1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118271887-A Zinc-aluminum coating composition, zinc-aluminum coating, preparation method of zinc-aluminum coating and zinc-aluminum coating-containing product 比亚迪股份有限公司 2024-07-02 CN claimed
CN-118271887-A Zinc-aluminum coating composition, zinc-aluminum coating, preparation method of zinc-aluminum coating and zinc-aluminum coating-containing product 比亚迪股份有限公司 2024-07-02 CN disclosed
EP-3707143-B9 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS ONCOSTELLAE S L (ES) 2023-04-12 EP disclosed
EP-3707143-B1 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS ONCOSTELLAE S L (ES) 2022-12-28 EP disclosed
US-11453660-B2 Androgen receptor and glucocorticoid receptor modulators ONCOSTELLAE, S.L. 2022-09-27 US disclosed
US-20200325123-A1 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS ONCOSTELLAE, S.L. (ES) 2020-10-15 US disclosed
EP-3707143-A1 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS Oncostellae, S.L. (ES) 2020-09-16 EP disclosed
CN-108203408-B Pyrazole compound containing N-aryl sulfonate as well as synthesis and application thereof 兰州大学 2020-07-21 CN disclosed
US-10385079-B2 Preparation method for tedizolid, tedizolid intermediate, and preparation method therefor ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) 2019-08-20 US disclosed
EP-3480201-A1 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS Oncostellae, S.L. (ES) 2019-05-08 EP disclosed
US-4650806-A Cardiotonic 5-(heterylcarbonyl)-pyridones STERLING DRUG INC. (US) 1987-03-17 US disclosed
EP-0210284-A1 1,3-Dithiol-2-ylidene derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1987-02-04 EP disclosed
EP-0191298-A2 1,6 -Naphthyridin-2(1H) - ones useful as cardiotonics and preparation thereof STERLING DRUG INC. (US) 1986-08-20 EP disclosed
US-4567186-A 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor STERLING DRUG INC. (US) 1986-01-28 US disclosed
US-4521422-A ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS AMERICAN CYANAMID COMPANY (US) 1985-06-04 US disclosed
EP-0129847-A2 Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones AMERICAN CYANAMID COMPANY (US) 1985-01-02 EP disclosed
US-4088764-A CARDIOVASCULAR DISORDERS, BETA-ADRENERGIC BLOCKING AGENTS, ANTIARRHYTHMIC AGENTS CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1978-05-09 US disclosed
US-4066768-A ADRENERGIC BLOCKING AGENTS, ANTIARRHYTHMIC CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1978-01-03 US disclosed
US-4018778-A ADRENALYTIC OR ANTIARRYTHMIC AGENTS CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1977-04-19 US disclosed
US-3940406-A HEART DISORDERS, PROPHYLAXIS CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10385079-B2 Preparation method for tedizolid, tedizolid intermediate, and preparation method therefor CYP51A1, CYP2F1, CYP4F11 PLOD2 4536/4885PLOD3 4675/4885PLOD1 4019/4885
US-20200325123-A1 NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS NR5A1, AR, NR3C1 PLOD2 1465/4885PLOD3 1643/4885PLOD1 1183/4885
US-11453660-B2 Androgen receptor and glucocorticoid receptor modulators AR, NR5A1, NR3C1 PLOD2 1601/4885PLOD3 1766/4885PLOD1 1329/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.