Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.58 |
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.58 |
| ▸ | BTK | Q06187 | 5/20 | 0.58 |
| ▸ | KIT | P10721 | 4/20 | 0.58 |
| ▸ | CSF1R | P07333 | 4/20 | 0.58 |
| ▸ | BRAF | P15056 | 8/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208690 | 0.84 | CSF1R (0.66) | LCKKDRMAPK14BTKKIT | |
| SCHEMBL17208637 | 0.82 | MAPT (0.61) | LCKKDRMAPK14BTKKIT | |
| SCHEMBL2855525 | 0.78 | LCK (0.60) | LCKKDRMAPK14BTKKIT | |
| SCHEMBL17208638 | 0.77 | EGFR (0.64) | LCKKITCSF1RBRAFABL1 | |
| SCHEMBL17208612 | 0.77 | MAPK14 (0.53) | LCKKDRMAPK14BTKKIT | |
| SCHEMBL374471 | 0.76 | PTGS1 (0.70) | LCKKDRMAPK14BTKKIT | |
| Hydrochloric Acid SCHEMBL5004557 | 0.75 | PTGS1 (0.68) | LCKKDRMAPK14BTKKIT | |
| SCHEMBL12858422 | 0.74 | MEN1 (0.73) | LCKKDRMAPK14BTKKIT | |
| SCHEMBL2944882 | 0.74 | LCK (1.00) | LCKKDRMAPK14BTKKIT | |
| SCHEMBL13220190 | 0.74 | LCK (0.76) | LCKKDRMAPK14BTKKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |