Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.76 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.76 |
| ▸ | NR2E1 | Q9Y466 | 8/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | LDLR | P01130 | 1/20 | 0.52 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 7/20 | 0.52 |
| ▸ | BCR | P11274 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FRK | P42685 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17244056 | 0.91 | MAP3K20 (0.63) | MAPK14MAP3K20NR2E1MAP3K7MAP4K2 | |
| SCHEMBL17208711 | 0.87 | MAPK14 (0.60) | MAPK14MAP3K20NR2E1MAP3K7MAP4K2 | |
| SCHEMBL17208706 | 0.86 | DDR1 (0.55) | MAPK14MAP3K20MAP3K7MAP4K2BRAF | |
| SCHEMBL17208620 | 0.83 | DDR1 (0.55) | MAPK14MAP3K20MAP3K7MAP4K2BRAF | |
| SCHEMBL16581560 | 0.81 | MAPK14 (0.76) | MAPK14MAP3K20NR2E1MAP3K7MAP4K2 | |
| SCHEMBL16581559 | 0.81 | MAPK14 (0.76) | MAPK14MAP3K20NR2E1MAP3K7MAP4K2 | |
| SCHEMBL24070682 | 0.78 | MAPK14 (0.69) | MAPK14MAP3K20NR2E1MAP3K7MAP4K2 | |
| SCHEMBL30447296 | 0.78 | MAPK14 (0.69) | MAPK14MAP3K20NR2E1MAP3K7MAP4K2 | |
| SCHEMBL17243860 | 0.78 | KCNK3 (0.53) | MAPK14MAP3K20MAP3K7MAP4K2DDR1 | |
| SCHEMBL29561954 | 0.75 | NR2E1 (1.00) | NR2E1KITLDLRPCSK9ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |