Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 1/20 | 0.55 |
| ▸ | MAP3K20 | Q9NYL2 | 6/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | CSK | P41240 | 3/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208706 | 0.97 | DDR1 (0.55) | DDR1MAP3K20MAPK14CSKMAP3K7 | |
| SCHEMBL17243860 | 0.88 | KCNK3 (0.53) | DDR1MAP3K20MAPK14CSKMAP3K7 | |
| SCHEMBL17208618 | 0.83 | MAPK14 (0.76) | DDR1MAP3K20MAPK14MAP3K7MAP4K2 | |
| SCHEMBL17244056 | 0.82 | MAP3K20 (0.63) | DDR1MAP3K20MAPK14CSKMAP3K7 | |
| SCHEMBL17208615 | 0.81 | DDR1 (0.82) | DDR1MAP3K20MAPK14CSKMAP3K7 | |
| SCHEMBL17208707 | 0.81 | MAPT (0.47) | DDR1KCNK3KCNK9ESR1MEN1 | |
| SCHEMBL17208613 | 0.81 | MAP3K20 (0.81) | DDR1MAP3K20MAPK14CSKMAP3K7 | |
| SCHEMBL17208650 | 0.79 | MAPT (0.56) | HTTMAPTRXFP1 | |
| SCHEMBL17208652 | 0.78 | PIKFYVE (0.56) | DDR1BRAFPIKFYVE | |
| SCHEMBL12518523 | 0.77 | LCK (0.64) | DDR1MAP3K20MAPK14CSKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |