Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208711 | 0.86 | MAPK14 (0.60) | MEN1KMT2ADDR1DDR2BRAF | |
| SCHEMBL17208706 | 0.84 | DDR1 (0.55) | MAPTMEN1KMT2APOLBTSHR | |
| SCHEMBL17208710 | 0.83 | MAP3K20 (0.64) | KMT2ADDR1EGFRBRAFRET | |
| SCHEMBL17208620 | 0.81 | DDR1 (0.55) | MAPTMEN1KMT2AESR1HTT | |
| SCHEMBL17208708 | 0.80 | MAPK14 (0.65) | KMT2ADDR1EGFRBRAFRET | |
| SCHEMBL26882896 | 0.77 | DDR1 (0.59) | DDR1DDR2EGFRBRAF | |
| SCHEMBL14689713 | 0.76 | DDR2 (0.60) | MAPTPOLBHTTLCKDDR1 | |
| SCHEMBL17208650 | 0.76 | MAPT (0.56) | MAPTPOLBHTTRXFP1 | |
| SCHEMBL14704746 | 0.75 | DDR2 (0.58) | MAPTPOLBHTTLCKDDR1 | |
| SCHEMBL17208652 | 0.75 | PIKFYVE (0.56) | LCKDDR1DDR2PIKFYVEBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9180127-B2 | Type II Raf kinase inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-11-10 | — | — | US | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |