Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.66 |
| ▸ | KIT | P10721 | 3/20 | 0.66 |
| ▸ | BRAF | P15056 | 12/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | BTK | Q06187 | 2/20 | 0.58 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208607 | 0.85 | ABL1 (0.60) | CSF1RKITBRAFLCKBTK | |
| SCHEMBL17208739 | 0.84 | LCK (0.58) | CSF1RKITBRAFKDRRAF1 | |
| SCHEMBL17208604 | 0.82 | CSF1R (0.62) | CSF1RBRAFKDRRAF1PDGFRA | |
| SCHEMBL27715420 | 0.78 | BRAF (0.76) | CSF1RKITBRAFKDRRAF1 | |
| SCHEMBL15127735 | 0.78 | BRAF (0.72) | CSF1RKITBRAFKDRRAF1 | |
| SCHEMBL2280193 | 0.77 | RAD52 (0.75) | BRAFBTKDDR1 | |
| SCHEMBL17208652 | 0.77 | PIKFYVE (0.56) | CSF1RKITBRAFKDRRAF1 | |
| SCHEMBL19073209 | 0.77 | BRAF (0.73) | CSF1RKITBRAFMAPK14LCK | |
| SCHEMBL3139304 | 0.77 | BMX (0.57) | CSF1RKITBRAFMAPK14LCK | |
| SCHEMBL22024518 | 0.76 | BRAF (0.69) | CSF1RKITBRAFMAPK14LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |
| EP-2937345-A2 | Type II raf kinase inhibitors | Dana-Farber Cancer Institute, Inc. (US) | 2015-10-28 | — | — | EP | disclosed |