Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 1.00 |
| ▸ | EGFR | P00533 | 3/20 | 0.85 |
| ▸ | JAK2 | O60674 | 2/20 | 0.85 |
| ▸ | FLT3 | P36888 | 2/20 | 0.85 |
| ▸ | BLK | P51451 | 2/20 | 0.85 |
| ▸ | BTK | Q06187 | 2/20 | 0.85 |
| ▸ | ITK | Q08881 | 2/20 | 0.85 |
| ▸ | JAK1 | P23458 | 1/20 | 0.85 |
| ▸ | TTK | P33981 | 1/20 | 0.85 |
| ▸ | TXK | P42681 | 1/20 | 0.85 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.68 |
| ▸ | BMX | P51813 | 1/20 | 0.68 |
| ▸ | CTSC | P53634 | 1/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.68 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.68 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.68 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.68 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30225760 | 0.92 | JAK3 (1.00) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL30925312 | 0.92 | JAK3 (1.00) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL17202389 | 0.92 | JAK3 (1.00) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL17209771 | 0.92 | JAK3 (0.85) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL17209775 | 0.90 | JAK3 (0.85) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL17209774 | 0.90 | JAK3 (0.86) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL17209773 | 0.87 | JAK3 (0.83) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL28053891 | 0.87 | JAK3 (0.77) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL24255239 | 0.86 | JAK3 (0.76) | JAK3EGFRJAK2FLT3BLK | |
| SCHEMBL17209829 | 0.86 | JAK3 (1.00) | JAK3EGFRJAK2FLT3BLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017477-B2 | Janus kinase inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-10017477-B2 | Janus kinase inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-9862688-B2 | Hydrophobically tagged janus kinase inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-01-09 | — | — | US | disclosed |
| US-20170044111-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-02-16 | — | — | US | disclosed |
| US-20170044111-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-02-16 | — | — | US | disclosed |
| US-20170044112-A1 | HYDROPHOBICALLY TAGGED JANUS KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-02-16 | — | — | US | disclosed |
| WO-2015164614-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044111-A1 | JANUS KINASE INHIBITORS AND USES THEREOF | JAK3, JAK1, JAK2 | JAK3 1/4885EGFR 692/4885JAK2 3/4885 |
| US-10017477-B2 | Janus kinase inhibitors and uses thereof | JAK3, JAK1, JAK2 | JAK3 1/4885EGFR 692/4885JAK2 3/4885 |
| US-20170044112-A1 | HYDROPHOBICALLY TAGGED JANUS KINASE INHIBITORS AND USES THEREOF | JAK1, JAK3, JAK2 | JAK3 2/4885EGFR 855/4885JAK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.