Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.56 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775733 | 0.84 | ROCK2 (0.77) | ROCK2ROCK1 | |
| SCHEMBL2777096 | 0.82 | ROCK2 (0.78) | ROCK2 | |
| SCHEMBL9883235 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| SCHEMBL9883139 | 0.78 | ROCK2 (0.72) | ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL112986 | 0.77 | ROCK2 (0.71) | ROCK2ROCK1 | |
| SCHEMBL22898421 | 0.76 | ROCK2 (0.78) | ROCK2ROCK1MYLK4 | |
| SCHEMBL20016619 | 0.76 | ROCK2 (0.82) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21412790 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21430778 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| SCHEMBL30607236 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3828172-A1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2021-06-02 | — | — | EP | disclosed |
| EP-2424842-B1 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS INC (US) | 2015-10-28 | — | — | EP | disclosed |