Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.82 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.82 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Netarsudil-M1 SCHEMBL21412824 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| Netarsudil-M1 SCHEMBL30607237 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| Netarsudil-M1 SCHEMBL21430354 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| Netarsudil-M1 SCHEMBL30607241 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| Netarsudil-M1 SCHEMBL9883166 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| Netarsudil-M1 SCHEMBL30692376 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| Netarsudil-M1 SCHEMBL30607238 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| Netarsudil-M1 SCHEMBL111706 | 0.89 | ROCK2 (0.98) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21412790 | 0.89 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 | |
| SCHEMBL21430778 | 0.89 | ROCK2 (1.00) | ROCK2ROCK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9931336-B2 | Combination therapy | AERIE PHARMACEUTICALS, INC. (US) | 2018-04-03 | — | — | US | disclosed |