Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTPRZ1 | P23471 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 7/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967680 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1TDP1PTPRZ1PTPN1 | |
| SCHEMBL9110897 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1TDP1PTPRZ1PTPN1 | |
| SCHEMBL3306143 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1TDP1PTPRZ1PTPN1 | |
| SCHEMBL3649499 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1TDP1PTPRZ1PTPN1 | |
| SCHEMBL27685083 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1TDP1PTPRZ1PTPN1 | |
| SCHEMBL27688226 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1TDP1PTPRZ1LMNA | |
| SCHEMBL27688227 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1TDP1PTPRZ1PTPN1 | |
| SCHEMBL1415320 | 0.74 | ESR1 (0.38) | TDP1LMNAHTT | |
| SCHEMBL18885111 | 0.73 | KDM4E (0.42) | KDM4EALDH1A1TDP1PTPRZ1PTPN1 | |
| SCHEMBL9774432 | 0.73 | SLC6A4 (0.48) | ALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406265-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102778-A2 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2010-09-16 | — | — | WO | disclosed |
| US-20100234419-A1 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | GRUNENTHAL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| CN-101048382-B | Novel indole or benzimidazole derivatives | HOFFMANN LA ROCHE | 2010-05-05 | — | — | CN | disclosed |
| CN-101048382-A | Novel Indole or Benzimidazole Derivatives | HOFFMANN LA ROCHE (CH) | 2007-10-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234419-A1 | SUBSTITUTED 3-AMINOISOXAZOLOPYRIDINES AS KCNQ2/3 MODULATORS | KCNQ1, KCNQ2, KCNQ3 | KDM4E 328/4885ALDH1A1 3278/4885TDP1 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.