Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12610671 | 0.85 | ALDH1A1 (0.41) | KDM4EALDH1A1TDP1SMN1; SMN2CETP | |
| SCHEMBL4550392 | 0.82 | KDM4E (0.38) | KDM4EALDH1A1TDP1SMN1; SMN2CETP | |
| Hydrochloric Acid SCHEMBL2717881 | 0.81 | KDM4E (0.37) | KDM4EALDH1A1TDP1SMN1; SMN2CETP | |
| SCHEMBL24781619 | 0.79 | HDAC4 (0.45) | KDM4EALDH1A1TDP1SMN1; SMN2CETP | |
| SCHEMBL27797879 | 0.78 | MAPT (0.39) | KDM4EALDH1A1SMN1; SMN2CETPLMNA | |
| SCHEMBL27797880 | 0.78 | LMNA (0.33) | KDM4EALDH1A1TDP1SMN1; SMN2CETP | |
| SCHEMBL27606147 | 0.78 | RXFP1 (0.38) | KDM4EALDH1A1TDP1SMN1; SMN2CETP | |
| SCHEMBL1721080 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1TDP1SMN1; SMN2LMNA | |
| SCHEMBL28041626 | 0.77 | CYP3A4 (0.41) | SMN1; SMN2MAPTMAPK1KCNH2POLB | |
| SCHEMBL11166250 | 0.76 | ESR1 (0.36) | KDM4EALDH1A1TDP1SMN1; SMN2CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101048382-B | Novel indole or benzimidazole derivatives | HOFFMANN LA ROCHE | 2010-05-05 | — | — | CN | disclosed |
| CN-101048382-A | Novel Indole or Benzimidazole Derivatives | HOFFMANN LA ROCHE (CH) | 2007-10-03 | — | — | CN | disclosed |