Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653656 | 0.90 | HTR2A (0.44) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL656147 | 0.90 | LTA4H (0.42) | HTR2AHTR7HRH1DRD2LTA4H | |
| SCHEMBL17476598 | 0.85 | HRH3 (0.42) | KDM4EHRH3HRH2HRH1 | |
| SCHEMBL655387 | 0.80 | PI4KB (0.53) | KDM4E | |
| SCHEMBL1694225 | 0.79 | PI4KB (0.48) | CYP3A4DRD2 | |
| SCHEMBL655075 | 0.77 | PI4KB (0.47) | KDM4ECYP3A4 | |
| SCHEMBL655575 | 0.76 | PI4KB (0.56) | CYP3A4 | |
| SCHEMBL794391 | 0.75 | PI4KB (0.52) | — | |
| SCHEMBL653832 | 0.74 | GFER (0.53) | HTR2AHTR2CHTR7HTR6HRH2 | |
| SCHEMBL652417 | 0.74 | DRD4 (0.43) | KDM4ECYP3A4CYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |