⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104329 | 0.69 | — | — | |
| SCHEMBL23061698 | 0.69 | TDP1 (0.33) | — | |
| SCHEMBL29249255 | 0.67 | — | — | |
| SCHEMBL29249247 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL29012713 | 0.67 | — | — | |
| SCHEMBL9490417 | 0.64 | — | — | |
| SCHEMBL22824811 | 0.64 | — | — | |
| SCHEMBL21478038 | 0.64 | — | — | |
| SCHEMBL278619 | 0.64 | — | — | |
| SCHEMBL24208209 | 0.64 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406242-B1 | PROCESS FOR THE PREPARATION OF RAMELTEON | IND CHIMICA SRL (IT) | 2013-06-05 | — | — | EP | disclosed |
| US-8242291-B2 | Process for the preparation of ramelteon | INDUSTRIALE CHIMICA S.R.L. (IT) | 2012-08-14 | — | — | US | disclosed |
| EP-2406242-A1 | PROCESS FOR THE PREPARATION OF RAMELTEON | Industriale Chimica S.R.L. (IT) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103553-A1 | PROCESS FOR THE PREPARATION OF RAMELTEON | INDUSTRIALE CHIMICA S.R.L. (IT) | 2010-09-16 | — | — | WO | disclosed |
| US-20100234622-A1 | PROCESS FOR THE PREPARATION OF RAMELTEON | INDUSTRIALE CHIMICA S.R.L (IT) | 2010-09-16 | — | — | US | disclosed |
| EP-0572918-B1 | Process for selectively ortho-fluorinating substituted aromatic compounds | AIR PROD & CHEM (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5453434-A | Ocular hypotensive agents, treatment of glaucoma | ALLERGAN, INC. (US) | 1995-09-26 | — | — | US | disclosed |
| EP-0572918-A1 | Process for selectively ortho-fluorinating substituted aromatic compounds | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1993-12-08 | — | — | EP | disclosed |
| US-5264449-A | Antiglaucoma agent, also treats dry eye disease | ALLERGAN, INC. (US) | 1993-11-23 | — | — | US | disclosed |
| US-5233074-A | Process for selectively ortho-fluorinating substituted aromatic compounds | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0138663-B1 | POLLEN SUPPRESSANT COMPRISING A PYRIDAZOLYAMINE | LAFARGE COPPEE (FR) | 1990-03-14 | — | — | EP | disclosed |
| US-4561881-A | HYBRIDS | LAFARGE COPPEE (FR) | 1985-12-31 | — | — | US | disclosed |
| EP-0138663-A2 | Pollen suppressant comprising a pyridazolyamine | LAFARGE COPPEE (FR) | 1985-04-24 | — | — | EP | disclosed |
| US-4391827-A | 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor | PFIZER INC. (US) | 1983-07-05 | — | — | US | disclosed |
| US-4306097-A | 3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |