Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | HPGD | P15428 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GRK6 | P43250 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540633 | 0.92 | MEN1 (0.40) | MEN1KMT2AKDM4ETDP1ALDH1A1 | |
| SCHEMBL18552348 | 0.90 | MEN1 (0.39) | MEN1KMT2AKDM4ETDP1ALDH1A1 | |
| SCHEMBL18540482 | 0.85 | MEN1 (0.40) | MEN1KMT2AKDM4ETDP1ALDH1A1 | |
| SCHEMBL17213103 | 0.84 | ALDH1A1 (0.39) | MEN1KMT2AKDM4ETDP1ALDH1A1 | |
| SCHEMBL17213153 | 0.83 | KDM4E (0.35) | KDM4ETDP1ALDH1A1GRK6CYP2C19 | |
| SCHEMBL17213081 | 0.81 | CYP19A1 (0.49) | MEN1KMT2AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL17215001 | 0.80 | MEN1 (0.39) | MEN1KMT2AKDM4ETDP1ALDH1A1 | |
| SCHEMBL18552354 | 0.80 | GRK6 (0.36) | KMT2AKDM4ERAB9AGRK6HSD17B10 | |
| SCHEMBL17213044 | 0.79 | GRK6 (0.34) | KMT2AKDM4ETDP1ALDH1A1HPGD | |
| SCHEMBL17212979 | 0.79 | TYMP (0.40) | ALDH1A1MAPTGRK6TYMPCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015164415-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-10-29 | — | — | WO | disclosed |