Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540629 | 0.92 | GRK6 (0.37) | KDM4EALDH1A1GRK6CYP2C19 | |
| SCHEMBL18552307 | 0.90 | KDM4E (0.38) | KDM4EALDH1A1GRK6RXRARXRB | |
| SCHEMBL18540472 | 0.85 | MAPT (0.34) | KDM4EALDH1A1GRK6CYP2C19 | |
| SCHEMBL21763872 | 0.85 | NR4A2 (0.36) | KDM4EALDH1A1GRK6RXRARXRB | |
| SCHEMBL17213155 | 0.83 | MEN1 (0.36) | KDM4EALDH1A1GRK6TDP1CYP2C19 | |
| SCHEMBL17213103 | 0.80 | ALDH1A1 (0.39) | KDM4EALDH1A1GRK6TDP1 | |
| SCHEMBL18552354 | 0.79 | GRK6 (0.36) | KDM4EGRK6 | |
| SCHEMBL18552406 | 0.79 | TP53 (0.35) | KDM4EALDH1A1GRK6TDP1 | |
| SCHEMBL18552357 | 0.78 | MAPT (0.39) | KDM4EALDH1A1GRK6TDP1 | |
| SCHEMBL17213122 | 0.77 | KDM4E (0.33) | KDM4EALDH1A1GRK6TDP1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134390-B1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-02-26 | — | — | EP | disclosed |
| WO-2015164415-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-10-29 | — | — | WO | disclosed |