Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 5/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147265 | 1.00 | DPP4 (0.35) | DPP4DPP8VNN1JAK3BTK | |
| SCHEMBL147266 | 1.00 | DPP4 (0.35) | DPP4DPP8VNN1JAK3BTK | |
| SCHEMBL179044 | 0.89 | RET (0.38) | DPP4DPP8VNN1JAK3BTK | |
| SCHEMBL8217907 | 0.79 | DPP4 (0.43) | DPP4DPP8VNN1JAK3BTK | |
| SCHEMBL31638498 | 0.78 | RET (0.43) | ACACBEIF2AK4 | |
| SCHEMBL149123 | 0.78 | EIF2AK4 (0.35) | VNN1JAK3BTKACACBEIF2AK4 | |
| SCHEMBL149122 | 0.78 | EIF2AK4 (0.35) | VNN1JAK3BTKACACBEIF2AK4 | |
| SCHEMBL149124 | 0.78 | EIF2AK4 (0.35) | VNN1JAK3BTKACACBEIF2AK4 | |
| SCHEMBL148610 | 0.78 | GPR119 (0.39) | GPR119 | |
| SCHEMBL8221580 | 0.77 | DPP4 (0.43) | DPP4DPP8VNN1JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406251-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |