Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.87 |
| ▸ | GAA | P10253 | 6/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24559426 | 0.93 | POLB (1.00) | POLBGAAHTTUSP2RECQL | |
| SCHEMBL24559315 | 0.88 | POLB (0.68) | POLBGAAHTTUSP2RECQL | |
| SCHEMBL15749725 | 0.81 | POLB (0.59) | POLBGAAPIM1ADORA2AADORA1 | |
| SCHEMBL10812553 | 0.79 | GAA (0.70) | POLBGAAHTTUSP2RECQL | |
| SCHEMBL17213617 | 0.78 | GAA (0.66) | POLBGAAHTTUSP2RECQL | |
| SCHEMBL15749724 | 0.78 | GAA (0.65) | POLBGAAHTTUSP2RECQL | |
| SCHEMBL3649360 | 0.78 | POLB (0.61) | POLBADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL24559433 | 0.76 | CYP2C9 (0.79) | POLBGAAADORA2AADORA1ADORA3 | |
| SCHEMBL15750029 | 0.76 | GAA (0.66) | POLBGAAHTTUSP2RECQL | |
| SCHEMBL15749705 | 0.76 | GAA (0.62) | POLBGAAHTTUSP2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109892-A1 | POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH | 2024-04-04 | — | — | US | disclosed |
| WO-2022159818-A1 | POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-07-28 | — | — | WO | disclosed |
| WO-2022159818-A1 | POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-07-28 | — | — | WO | disclosed |
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-06-30 | — | — | US | disclosed |
| WO-2020205646-A2 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-10-08 | — | — | WO | disclosed |
| US-9546176-B2 | Small molecule bicyclic and tricyclic CFTR correctors | DISCOVERYBIOMED, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-20150307503-A1 | SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS | DISCOVERYBIOMED, INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109892-A1 | POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME | MACROD2, MACROD1, PARG | POLB 621/4885GAA 157/4885HTT 1543/4885 |
| US-20150307503-A1 | SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS | CFTR, CLCN2, CLIC1 | POLB 3476/4885GAA 1041/4885HTT 2076/4885 |
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | PARG, PARP15, PLG | POLB 1840/4885GAA 2742/4885HTT 3550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.