Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10812553 | 0.85 | GAA (0.70) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL17213617 | 0.83 | GAA (0.66) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL15749724 | 0.83 | GAA (0.65) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL15750029 | 0.81 | GAA (0.66) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL8746993 | 0.79 | GAA (0.67) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL15750017 | 0.78 | CYP2D6 (0.50) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL24559315 | 0.78 | POLB (0.68) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL14027516 | 0.77 | HTT (0.64) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL516338 | 0.76 | GAA (0.62) | GAAHTTUSP2RECQLPOLB | |
| SCHEMBL8445877 | 0.76 | ALDH1A1 (0.74) | POLBALOX15HSD17B10CYP2D6ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546176-B2 | Small molecule bicyclic and tricyclic CFTR correctors | DISCOVERYBIOMED, INC. (US) | 2017-01-17 | — | — | US | disclosed |
| US-20150307503-A1 | SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS | DISCOVERYBIOMED, INC. (US) | 2015-10-29 | — | — | US | disclosed |
| WO-2014081821-A2 | Small Molecule Bicyclic and Tricyclic CFTR Correctors | DISCOVERYBIOMED, INC. (US) | 2014-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307503-A1 | SMALL MOLECULE BICYCLIC AND TRICYCLIC CFTR CORRECTORS | CFTR, CLCN2, CLIC1 | GAA 1041/4885HTT 2076/4885USP2 2182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.