Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 2/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926744 | 1.00 | S1PR1 (0.37) | S1PR1S1PR5CHRM2CHRM3CHRM1 | |
| SCHEMBL3926747 | 1.00 | S1PR1 (0.37) | S1PR1S1PR5CHRM2CHRM3CHRM1 | |
| SCHEMBL3919419 | 0.90 | DRD2 (0.37) | DRD4DRD2DRD3SIGMAR1HTR4 | |
| SCHEMBL3919422 | 0.90 | DRD2 (0.37) | DRD4DRD2DRD3SIGMAR1HTR4 | |
| SCHEMBL458397 | 0.87 | KMT2A (0.42) | L3MBTL1DRD4DRD2DRD3KMT2A | |
| SCHEMBL148557 | 0.87 | KMT2A (0.42) | L3MBTL1DRD4DRD2DRD3KMT2A | |
| SCHEMBL148558 | 0.87 | KMT2A (0.42) | L3MBTL1DRD4DRD2DRD3KMT2A | |
| SCHEMBL3932202 | 0.81 | DPP4 (0.47) | S1PR1S1PR5CHRM2CHRM3FUCA1 | |
| SCHEMBL3932194 | 0.81 | DPP4 (0.47) | S1PR1S1PR5CHRM2CHRM3FUCA1 | |
| SCHEMBL3932267 | 0.81 | L3MBTL1 (0.41) | S1PR1S1PR5L3MBTL1POLBDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406251-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103334-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |