Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799139 | 0.68 | RIPK1 (0.48) | HTTKDM4EFGFR4 | |
| SCHEMBL805085 | 0.64 | ALDH1A1 (0.40) | HTTKDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL799359 | 0.64 | ALDH1A1 (0.46) | HTTKDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL799274 | 0.62 | PIK3CG (0.53) | HTTKDM4EALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL20086444 | 0.61 | KDM4E (0.69) | HTTKDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL798614 | 0.60 | PDE4A (0.45) | HTTKDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL18181910 | 0.59 | ALDH1A1 (0.64) | HTTKDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL1463228 | 0.59 | GRIK1 (0.73) | HTTKDM4EALDH1A1PKMRAB9A | |
| SCHEMBL10988985 | 0.58 | ALDH1A1 (0.63) | HTTKDM4EALDH1A1CYP1A2POLB | |
| SCHEMBL22573598 | 0.58 | ATR (0.47) | HTTKDM4EALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426135-A1 | UREA DERIVATIVE HAVING PI3K INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |