Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724686 | 0.86 | CCNC (0.49) | KMOKMT2AKDM4EMMP2ALDH1A1 | |
| SCHEMBL1725126 | 0.83 | KMO (0.53) | KMOKMT2AKDM4EMMP2ALDH1A1 | |
| SCHEMBL9907329 | 0.81 | KDM4E (0.62) | KMT2AKDM4EMMP2PARP1MEN1 | |
| SCHEMBL1724445 | 0.79 | KDM4E (0.49) | KMT2AKDM4EMMP2MEN1 | |
| SCHEMBL13187923 | 0.79 | NPC1 (0.52) | KMT2AKDM4EALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL13187295 | 0.78 | KMT2A (0.50) | KMT2AALDH1A1RORCRORB | |
| SCHEMBL13187921 | 0.78 | KMT2A (0.53) | KMT2AMEN1 | |
| SCHEMBL1722035 | 0.78 | NFKBIA (0.43) | KDM4EALDH1A1SMN1; SMN2XDHPIN1 | |
| SCHEMBL1722034 | 0.78 | ADORA2A (0.43) | KDM4EXDHRORCRORBPARP1 | |
| SCHEMBL1721909 | 0.77 | FGFR4 (0.46) | KMOKMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102414180-A | 8-substituted quinolines and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-04-11 | — | — | CN | disclosed |
| EP-2403833-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |