Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722252 | 0.85 | SLC6A2 (0.40) | — | |
| SCHEMBL9907329 | 0.81 | KDM4E (0.62) | KDM4EKMT2AMMP2MGAMALOX15 | |
| SCHEMBL27847478 | 0.81 | KDM4E (0.38) | KDM4ENOTUM | |
| SCHEMBL1721889 | 0.79 | KMO (0.52) | KDM4EKMT2AMMP2MEN1 | |
| SCHEMBL1722251 | 0.79 | AKR1C3 (0.38) | KDM4EKMT2ARXRARXRBRXRG | |
| SCHEMBL27847477 | 0.79 | PIM1 (0.36) | ALOX15TSHRNOTUMLMNA | |
| SCHEMBL13187214 | 0.78 | SIRT2 (0.47) | TDP1LMNA | |
| SCHEMBL13187636 | 0.78 | SIRT2 (0.47) | KDM4EKMT2ATSHR | |
| SCHEMBL13187254 | 0.77 | SIRT2 (0.48) | KDM4EKMT2AALOX15TSHRMEN1 | |
| SCHEMBL13187919 | 0.77 | NPC1 (0.53) | KMT2AMGAMTSHRMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102414180-A | 8-substituted quinolines and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-04-11 | — | — | CN | disclosed |
| EP-2403833-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |