Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | THRA | P10827 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107436 | 0.85 | PLA2G7 (0.42) | PLA2G7BRAFRAF1CYP3A4HDAC1 | |
| SCHEMBL9104815 | 0.79 | PLA2G7 (0.49) | PLA2G7BRAFRAF1CDK8AURKA | |
| SCHEMBL9101618 | 0.78 | PLA2G7 (0.41) | PLA2G7BRAFRAF1CYP3A4 | |
| SCHEMBL17219901 | 0.78 | PLA2G7 (0.41) | PLA2G7BRAFRAF1CYP3A4HDAC1 | |
| SCHEMBL9108042 | 0.77 | PLA2G7 (0.43) | PLA2G7BRAFRAF1CYP3A4CDK8 | |
| SCHEMBL9103344 | 0.75 | PLA2G7 (0.47) | PLA2G7BRAFRAF1CDK8AURKA | |
| SCHEMBL9889713 | 0.74 | LMNA (0.35) | PLA2G7CYP3A4CDK8 | |
| SCHEMBL9101643 | 0.73 | PLA2G7 (0.48) | PLA2G7BRAFRAF1CYP3A4CDK8 | |
| SCHEMBL9889702 | 0.72 | PLA2G7 (0.36) | PLA2G7CYP3A4 | |
| SCHEMBL9106828 | 0.71 | PLA2G7 (0.48) | PLA2G7BRAFRAF1CYP3A4CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649053-B1 | PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP-PLA2 | GLAXO GROUP LTD (GB) | 2015-11-04 | — | — | EP | disclosed |