Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 3/20 | 0.32 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.31 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726672 | 0.80 | METAP2 (0.33) | NPC1LMNATP53MAPK1RAB9A | |
| SCHEMBL15134553 | 0.75 | NPC1 (0.35) | NPC1LMNATP53MAPK1RAB9A | |
| SCHEMBL80348 | 0.75 | ALDH1A1 (0.43) | NPC1LMNATP53MAPK1RAB9A | |
| SCHEMBL1710639 | 0.73 | AR (0.34) | — | |
| SCHEMBL1710557 | 0.73 | AR (0.34) | — | |
| SCHEMBL1722592 | 0.73 | PSEN1 (0.34) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL77546 | 0.73 | KMT2A (0.40) | NPC1LMNATP53MAPK1RAB9A | |
| SCHEMBL3390189 | 0.72 | AR (0.36) | NPC1LMNATP53MAPK1RAB9A | |
| SCHEMBL3383770 | 0.72 | AR (0.36) | NPC1LMNATP53MAPK1RAB9A | |
| SCHEMBL1710712 | 0.72 | AR (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |