Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17292437 | 1.00 | LMNA (0.32) | LMNATSHRALDH1A1TP53CYP2D6 | |
| SCHEMBL3861339 | 0.80 | HTT (0.39) | HTT | |
| SCHEMBL1504120 | 0.80 | HTT (0.39) | HTT | |
| SCHEMBL64217 | 0.80 | HTT (0.39) | HTT | |
| SCHEMBL13286598 | 0.76 | MTNR1A (0.33) | CYP2D6 | |
| SCHEMBL14249956 | 0.76 | GAA (0.49) | ALDH1A1 | |
| SCHEMBL14249955 | 0.76 | GAA (0.49) | ALDH1A1 | |
| SCHEMBL15591379 | 0.75 | NR1I2 (0.31) | — | |
| SCHEMBL17236154 | 0.74 | — | — | |
| SCHEMBL17236116 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450325-B2 | Processes of preparing a JAK1 inhibitor and new forms thereto | INCYTE CORPORATION (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180099978-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | INCYTE CORPORATION | 2018-04-12 | — | — | US | disclosed |
| US-9802957-B2 | Processes of preparing a JAK1 inhibitor and new forms thereto | INCYTE CORPORATION (US) | 2017-10-31 | — | — | US | disclosed |
| EP-3137471-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | Incyte Corporation (US) | 2017-03-08 | — | — | EP | disclosed |
| US-20150344497-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | INCYTE CORPORATION (US) | 2015-12-03 | — | — | US | disclosed |
| WO-2015168246-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | INCYTE CORPORATION (US) | 2015-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450325-B2 | Processes of preparing a JAK1 inhibitor and new forms thereto | JAK1, JAK2, JAK3 | LMNA 3727/4885TSHR 2362/4885ALDH1A1 2222/4885 |
| US-20180099978-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | JAK1, JAK2, JAK3 | LMNA 3727/4885TSHR 2362/4885ALDH1A1 2222/4885 |
| US-20150344497-A1 | PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO | JAK1, JAK2, JAK3 | LMNA 3727/4885TSHR 2362/4885ALDH1A1 2222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.