Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 12/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | CASP6 | P55212 | 2/20 | 0.70 |
| ▸ | NSD2 | O96028 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 8/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | MMP14 | P50281 | 1/20 | 0.67 |
| ▸ | GLO1 | Q04760 | 6/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17224291 | 1.00 | MEN1 (0.70) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL17224403 | 0.89 | MEN1 (0.55) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL17224405 | 0.89 | MEN1 (0.55) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL5851373 | 0.80 | GLO1 (0.88) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL5851384 | 0.80 | GLO1 (0.88) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL4465316 | 0.77 | GLO1 (1.00) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL4465315 | 0.77 | GLO1 (1.00) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL13625080 | 0.77 | COMT (0.58) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL18540745 | 0.77 | MEN1 (0.44) | MEN1KMT2AHSP90AA1NPC1CASP6 | |
| SCHEMBL4452808 | 0.77 | MEN1 (1.00) | MEN1KMT2AHSP90AA1NPC1CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137554-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | Ecole Normale Superieure De Lyon (FR) | 2017-03-08 | — | — | EP | disclosed |
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | disclosed |
| US-20170051149-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2017-02-23 | — | — | US | disclosed |
| WO-2015166295-A1 | AZOARYLS AS REVERSIBLY MODULATABLE TUBULIN INHIBITORS | ECOLE NORMALE SUPERIEURE DE LYON (FR) | 2015-11-05 | — | — | WO | disclosed |